UA: Breast Cancer Therapy Associated With Reduced Risk Of Neurodegenerative Disease In Women

first_imgUA News:TUCSON, Ariz. — Findings from an investigative study at the Center for Innovation in Brain Science at the University of Arizona Health Sciences have shown that, for women with breast cancer, exposure to hormone-modulating therapies was associated with a significant decrease in the number of women who received a diagnosis of neurodegenerative disease – more specifically Alzheimer’s disease.The center’s investigation, which was published in JAMA Network Open this past spring, surveyed medical insurance claims from private-payer and Medicare data to identify premenopausal, menopausal or postmenopausal patients who had been diagnosed with breast cancer to determine whether those women receiving hormone-modulating therapies had a different risk of developing a neurodegenerative disease. “This retrospective cohort study provides a clear message: breast cancer therapies do not increase the risk of age-related neurodegenerative diseases, like Alzheimer’s and Parkinson’s. Critically, these therapies can actually reduce the risk of developing these diseases, ” said Center Director Roberta Diaz Brinton, PhD. “As life expectancies after treatment increase for breast cancer patients, this study further illustrates the importance of evaluating personalized treatment options that may result in a reduced risk of neurodegenerative diseases like Alzheimer’s.”According 2019 statistics from BreastCancer.org, breast cancer is the second most common cancer in women and 12.8% of women (1 in 8) will receive a breast cancer diagnosis in their lifetime. It is predicted the number of women living with breast cancer and at risk for other diseases will escalate, in the aging population especially. At the same time, women are at a two-fold greater lifetime risk than men for developing Alzheimer’s disease. The study’s lead author, Gregory Branigan, a predoctoral fellow, is part of the UArizona MD/PhD Program, which offers dual training in both medicine and biomedical research, and is conducting his doctoral research in Dr. Brinton’s laboratory. Collaborators include Kathleen Rodgers, PhD, Maira Soto, PhD, and noted breast cancer surgeon Leigh Neumayer, MD, former surgery department head at the UArizona College of Medicine – Tucson now at the University of Florida College of Medicine in Jacksonville.Dr. Brinton also is a UArizona professor in the Department of Neurology and Pharmacology in the College of Medicine – Tucson and Department of Psychology in the UArizona College of Science. The UArizona Center for Innovation in Brain Science continues to pursue research through an innovative “all brains on deck” approach, in order to reduce the global burden of Alzheimer’s and other neurodegenerative diseases.This study was supported by grants from the National Institute on Aging: Perimenopause in Brain Aging and Alzheimer’s Disease (P01AG026572); Translational Research in Alzheimer’s Disease and Related Dementias – TRADD (T32AG061897); and Aging and Estrogenic Control of the Bioenergetic System in Brain (R37AG053589); and funding from the Women’s Alzheimer’s Movement to Dr. Brinton’s research.last_img read more

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Helium facilities to be commissioned in Qatar in Q4

first_imgSubscribe Get instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270.last_img

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PPG Group obtains international best practice certification

first_imgPPG general manager Kevin Stephens said the certification acknowledged international best practice for the global network through memberships, project forwarding training, annual conference arrangements, exhibition attendance and marketing services.”This certification demonstrates PPG’s continuous improvement and customer focus in line with proven management principles. “These business systems ensure a step-by-step approach that benefits members and clients by ensuring effectiveness, efficiency and confidence in PPG’s capabilities.”PPG member in the United States, TransProject LLC, also achieved the ISO 9001:2008 certification this month.last_img read more

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Cinderella sparkles at Baxter holiday panto

first_imgAugusta (Kyle Seconna) and Petronella (Andrew Lightley) find that the Prince (Rachelle Kruger) only has eyes for Cinderella (Monique Rockman) in a scene from Cinderella at the Baxter. The Lilliput Children’s Theatre Company will stage the pantomime, Cinderella, at the Baxter Theatre in December from Monday December 19 to Saturday December 24, at 10.30am. This contemporary version of the classic fairy tale is written and directed by Elton John Duffy, of Edgemead. It will have lots of audience participation and popular songs from Justin Bieber, Black Eyed Peas, Bruno Mars, Justin Timberlake and Roxette. It stars Desle McConney, of Athlone, as Buttons; Liande Valentyn, of Grassy Park, as the Fairy Godmother; Shaun Klaasen, of Rondebosch, as Prince Charming; Andrew Lightley, of Cape Town, as Augusta; Kyle Seconna, of Somerset West, as Petronella; Carmen Maarman, of Belhar, as William; and Monique Rockman, of Blue Downs, as Cinderella. Tickets are R75 and available through Computicket or any Shoprite or Checkers store. For block bookings or queries, call Elton at 083 364 8284 or 021 558 2650. Visit www.lilliputplayers.co.za for more information.last_img read more

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Bar Conference: Moses targets Grayling on ‘rule of law’

first_imgFormer lord justice of appeal Sir Alan Moses drew spontaneous applause at last Saturday’s Bar Conference with a withering attack on lord chancellor Chris Grayling.Sir Alan (pictured, centre), now chair of the new Independent Press Standards Organisation, alluded to the threat to the bar posed by having non-lawyers in senior positions at the Ministry of Justice.Delivering the closing keynote speech, Sir Alan said: ‘I hope the public appreciates the need to cherish and cultivate those who seek to provide powerful and independent advocacy.‘This is all the more important today when you are faced with no one in power and authority ready to speak up on your behalf. You have a lord chancellor whose idea of the “rule of law” is to deprive what he describes as “foreigners” of access to the courts, supported by a permanent secretary [Ursula Brennan] who is not a qualified lawyer.‘Was that envisaged in the 2005 [Constitutional Reform] Act [which reformed the role of lord chancellor]?’Sir Alan was among the judges who in July thwarted the lord chancellor’s attempt to restrict the availability of legal aid to people who could show they had lived in Britain for at least a year. The High Court ruled that this amounted to unlawful discrimination.Sir Alan also took aim at the government over the sackings of law officers Dominic Grieve and Sir Edward Garnier QC, and their replacement with relatively inexperienced barristers.Both were perceived to have paid the price for their defence of human rights. Sir Alan added: ‘Did you believe in all your lifetime you would see the government’s two leading lawyers lose their jobs because they gave their genuine opinion?’Grieve was succeeded by junior barrister Jeremy Wright MP, the first non-QC in living memory to hold the post (he received the rank on his promotion). Robert Buckland MP, a door tenant at 23 Essex Street, became solicitor general in July, replacing Oliver Heald.Sir Alan conceded that the two ‘young men’ may prove highly distinguished occupants of the roles, but added: ‘They did not manifest their distinction by knocking around the courts or appearing in front of juries. Do you expect them to speak up on your behalf?’last_img read more

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Rajasthan test track plan endorsed

first_imgINDIA: The national government has approved plans to develop a 40 km dedicated test track in Rajasthan for railway research and testing. This is expected to reduce the requirement for new and experimental trains to be tested on the increasingly busy national network.IR’s Research, Design & Standards Organisation had issued an initial request for proposals in September for an international consultant to assist with the development of testing facilities to support the operation at speeds above 160 km/h. On January 21 the government announced that the test track had been designated as a ‘special railway project’, which is intended to speed up the approval and land acquisition process as well as facilitating the necessary construction work.The preferred site for the new centre incorporates part of the former North Western Railway main line between Phulera and Jodhpur, where the converted metre gauge section between Gudha and Thathana Mithri has been bypassed by a new alignment.The Rs4bn first stage investment will see the development of a 25 km test track with around 20 km of straight track and 5 km of curves with radii of 1 750 m and 875 m. This will replicate the current specifications that apply to IR’s 1 676 mm gauge main lines, including structures and curvature.According to an IR spokesman, ‘testing a new technology or train on a dedicated track is like conducting an experiment in a laboratory. This will be an all-weather track and will have all the prerequisites of a regular track.’ The new facility is to be used for a wide variety of tests, including ride quality, emergency braking and coupler force measurements which are deemed essential to ensure the safe operation of both freight and passenger trains.Emphasising the increasing challenge of finding spare capacity for testing on main lines, former IR Board Member (Traffic) V N Mathur explained that the railway had been criticised by the Commissioner of Railway Safety in August 2016 for conducting 180 km/h trials with a Talgo trainset on the busy Delhi – Mumbai corridor.last_img read more

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The Greatest Dancer kicks off series 2 on Saturday night – preview the first episode

first_img Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thamescenter_img Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames The Greatest Dancer returns for a second series on Saturday night on BBC One.Cheryl, Matthew Morrison and Oti Mabuse are back as Dance Captains and this year they’ll be joined by Todrick Hall, best-known for his innovative choreography and viral YouTube videos. Alesha Dixon and Jordan Banjo are back to present and Love Island star Curtis Pritchard will be manning the reception desk as the hopefuls arrive.The show will see dancers of all ages and dance styles compete to win £50,000 and a chance to perform on Strictly Come Dancing. During the auditions, the audience holds the power. If they are impressed by the audition, they will vote to open the mirror, if 75 percent of the audience vote YES, the mirror will open and the dancer will make it through to the next stage of the competition, the call backs.There is a new twist for this series, where one Dance Captain will be given the power to choose their ’Greatest Dancer of the Day’ at the end of each episode, offering them a guaranteed place on their team and a fast track straight through to the live shows.The first series saw Oti Mabuse and her dancer Ellie win the competition. Can she win again this year or will it be one of the other Dance Captains?The Greatest Dancer series 2 kicks off at 7pm Saturday on BBC One. Preview it with our gallery below: Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thames Credit: BBC/Syco/Thameslast_img read more

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Peregrine Releases UltraCMOS® Antenna Tuning Switch Optimized for High Performance, Ultra-Thin LTE-Advanced Smartphones

first_imgPeregrine Semiconductor has announced a single-pole, single throw (SPST) antenna tuning switch for LTE-Advanced (LTE-A) smartphones. This switch leverages Peregrine’s UltraCMOS® process using the HaRP™ and DuNE™ enhancements to deliver an ideal combination of performance and integration to 4G wireless platforms. The PE613010 antenna switch delivers the industry’s lowest resistance-on (Ron) of 1.2 Ohms from 700-2700MHz. This maximizes radiated performance of the antenna in support of higher data throughput, increased battery life and longer range for fewer dropped calls. Manufacturers can achieve this performance while also minimizing size in support of thinner form factor phones. The new PE613010 antenna tuning switch is supplied in a miniature 2 x 2 x 0.55 mm package that requires zero external components. Peregrine’s tuning products are designed to help 4G handset manufacturers implement tunable antennas, the benefits of which include faster data throughput, smaller size and enhanced overall consumer experience. The PE613010 antenna tuning switch has already been chosen by Pantech to drive performance in its new Vega LTE-A handset. “The emergence of LTE-A networks places significant RF design challenges on handset manufacturers to deliver an optimal user experience despite supporting the ever increasing number of frequency bands and higher data throughput,” said Dylan Kelly, vice president of the mobile wireless solutions business unit at Peregrine Semiconductor.  “The new PE613010 antenna tuning switch helps to solve these challenges, and as a result, has already been integrated into multiple 4G handsets. The feedback from customers has been very positive as Peregrine’s tuning solutions enable the performance gains required at the antenna for smartphones to support the full capabilities of LTE-A networks.” The PE613010 antenna tuning switch features high RF power handling and ruggedness, while meeting challenging harmonic and linearity requirements of LTE-A with Peregrine’s HaRP technology. With single-pin low voltage CMOS control, all decoding and biasing is integrated on-chip and no external bypassing or filtering components are required.  The PE613010 also features ESD tolerance of 2kV HBM on all pins, providing a monolithically integrated solution for tunable antennas.last_img read more

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Thomas Leads UWF to Victory in Final Minute of GSC Opener

first_imgThomas Leads UWF to Victory in Final Minute of GSC Opener Maurice Thomas (Photo by Ron Besser) Sharecenter_img PENSACOLA, Fla. – Senior Maurice Thomas (Milton, Fla./Pensacola JC) scored the go-ahead basket with 23 seconds left and blocked a potential game-winning shot on the next possession in the West Florida men’s basketball team’s 75-73 win over West Alabama in the Gulf South Conference opener at the UWF Field House on Thursday.  Five Argonauts scored in double digits, as West Florida improved to 7-6 overall and 1-0 in GSC play.  West Alabama fell to 8-8, 0-1 with the loss.UWF went up big in the first half, jumping out to a 17-point lead at 29-12 with 7:06 left in the opening period.  After being down by 11 at halftime, West Alabama chipped away at the UWF lead until finally tying the score at 73-73 on a Chris Davis jumper with a minute left in the game.  Thomas held the ball on the perimeter for UWF on the next possession, and with the shot clock running out, he pulled up for a 20-foot jumper and drained it to put the Argos up by two.  UWA scrambled to come up with a shot on their final possession, and a last ditch three-point attempt by Alquan Mendenhall was rejected by Thomas, clinching the 75-73 win.Junior Ken Mitchell (Mobile, Ala./Alabama Southern CC) led the way for West Florida on both ends with 19 points, eight rebounds, and four blocked shots.  Mitchell was 9-12 from the floor, improving his field goal percentage for the season to 62 percent.  Senior Jonathan Jackson (Pensacola, Fla./Johnson County CC) added 14 points, while freshman Peter Connole was 5-7 from the field and scored 12 for the Argonauts.UWF finished the night with an even 50 percent (29-58) performance from the field, and the Argos also outrebounded the Tigers 36-29.  Mitchell, Jackson, and senior Max Hoggard (Micanopy, Fla./P.K. Yonge HS) each had eight rebounds for UWF.  The rebounds proved to be a difference for the Argos, as UWF had 17 second chance points compared to just three for the Tigers.Mendenhall, who had his three-pointer blocked in the final seconds, finished the night 7-13 from long range and led the Tigers with a game-high 23 points.  Jason Swanson added 14 points and nine rebounds.  The UWF defense held Richard Sirju, a 56.3 percent three-point shooter averaging 15.5 points per game entering Thursday, to just three points.UWF will look to pick up another conference win this Saturday against visiting Alabama-Huntsville, and tip-off is scheduled for 4:00 p.m.  For information on all UWF Athletics, visit www.GoArgos.com. Print Friendly Versionlast_img read more

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Conference Committee Reaches State Budget Compromise

first_imgFacebookTwitterEmailPrintFriendly分享A State Conference Committee has reached a compromise on budget negotiations, but the bill must still be approved by the House and Senate. The compromise was announced last night. MacKinnon says as they wrap up the special legislative session, she looks forward to “continued compromise on those critical pieces for the people of Alaska.” Senator Anna MacKinnon says the process wasn’t easy, but “the bodies and the caucuses came together and worked out a compromise to fund the people’s government and continue services Alaskans rely upon.”center_img The deal restores funding for public schools, softens a cut to the university system and will prevent the need to send pink slips to state workers.last_img read more

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