SA, Botswana in rhino translocation deal

first_img The project has the support of the Botswana Rhino Management Committee, as well as assistance from the Eastern Cape’s Chipembere Rhino Foundation for telemetry and tracking equipment being used by the game scouts. 11 March 2013 South African travel company andBeyond’s Phinda private game reserve in KwaZulu- Natal is involved in a groundbreaking deal to translocate six white rhino to Botswana’s Okavango Delta. It has been reported as the first private game reserve donation of rhino to another country. The translocation began in February following years of negotiation and planning. It is still under way. “The Okavango Delta has proven to be a successful rhino relocation habitat and Botswana has a strong security and monitoring framework in place whereby the military helps to protect the species,” andBeyond said in a statement at the start of the translocation process on 8 February. Game scouts from Botswana received tracking and monitoring training from Phinda to assist with the move. “The movement and behaviour of the six rhino will be closely monitored using satellite collars and telemetry and tracking equipment,” the company said. It forms part of andBeyond’s rhino protection efforts, which fall under its Care of the Land, Care of the Wildlife, Care of the People vision. The translocation was facilitated in partnership with conservation organisation Rhino Force and funded by insurance administrator Motorite Administrators. It follows in the wake of a 49% increase in illegal poaching in 2012, when 668 rhinos were killed in South Africa. “Botswana has an excellent security system in place to protect these endangered animals and will be a safe haven for the six relocated rhino,” said andBeyond CEO, Joss Kent. “Translocations are fundamental to secure the ongoing survival of endangered species and this groundbreaking project led by andBeyond’s conservation team aims to increase Africa’s dwindling rhino populations for future generations to enjoy.” SAinfo reporterlast_img read more

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News.me Exposé Puts Your Friends In Charge of the News

first_imgTags:#Product Reviews#web I’ve been playing around with a new tool from the crack team at News.me called Exposé. It’s a browser bookmarklet that shows you what a news site would look like “if [y]our friends were in charge.” It pops up a News.me menu that lists stories from that site your Twitter, Facebook and News.me friends have shared, along with their comments.News.me makes iOS apps and email digests that pull in news from your social networks, and Exposé is a remarkable extension of that technology. It lets you quickly jump to the stories likely to matter to you on any site. Top Reasons to Go With Managed WordPress Hosting Why Tech Companies Need Simpler Terms of Servic… 8 Best WordPress Hosting Solutions on the Market jon mitchell Related Posts News.me is making reactions to the news into a social layer. Lots of services are able to digest your Twitter and Facebook streams and pull out the most popular links, but News.me is doing more with the data. Especially with the new reactions in the iPhone app, News.me provides a bunch of quick signals about what your contacts thought of a story.The News.me iPhone app is a good place to discover new stories and sources. But I also launch it when I know there’s news, because I’ll immediately be able to identify which take on the story is the one I need to see.The new bookmarklet extends that power to the Web as well. If your network is talking about any stories on a site you’re visiting, you can reveal them in one click.Not only is it a handy filter for an avid reader, it’s a great reason to convince your friends to use News.me. But they don’t even have to; just posting the links on Twitter or Facebook will cause them to show up in your Exposé.You can find Exposé on the News.me/tools page.Lead image courtesy of Shutterstock A Web Developer’s New Best Friend is the AI Wai…last_img read more

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Gene editing of dogs offers hope for treating human muscular dystrophy

first_img By Jon CohenAug. 30, 2018 , 2:00 PM About 13% of boys with DMD have mutations in a region between exon 45 and 50, which bumps exon 51 “out of frame” and throws a wrench into the cellular machinery that reads the gene’s instructions, stopping production of dystrophin. In 2009, a team led by Richard Piercy at the Royal Veterinary College in London identified a spaniel with signs of DMD that had a spontaneous mutation deleting exon 50, which similarly moves exon 51 out of frame. They later bred a relative of that dog with beagles, which have long been used in biomedical research, to create a colony with DMD symptoms.Together with Piercy’s group, Olson and colleagues designed CRISPR’s molecular scissors to make a cut at the beginning of exon 51 in the diseased beagles. The team hoped that when the cell tried to repair the slice, it would accidentally introduce errors to exon 51, leading its proteinmaking machinery to skip the exon altogether and produce a shortened but still functional dystrophin. (A newly approved drug for DMD, eteplirsen, promotes such exon-skipping as well, but its efficacy remains hotly debated.)Another challenge was to alter billions of muscle cells throughout a living animal. So the team enlisted a helper: a harmless adeno-associated virus that preferentially infects skeletal muscle and heart tissue. Two 1-month-old dogs received intramuscular injections of the virus, engineered to carry CRISPR’s molecular components. Six weeks later, those muscles were making dystrophin again. Those results led the researchers to give an intravenous infusion to two more dogs, also 1 month old, to see whether the CRISPR-carrying viruses could add the genome editor to muscles throughout the body. By 8 weeks, Olson told the meeting, dystrophin levels climbed to relatively high levels in several muscles, reaching 58% of normal in the diaphragm and 92% in the heart. But because the dogs were euthanized, Olson could show little evidence that they had avoided DMD symptoms, save for a dramatic video of a treated dog walking and jumping normally.”There are a lot of questions that have to be addressed,” acknowledges Leonela Amoasii, who works in Olson’s lab at UT Southwestern and is director of gene editing at Exonics. Skeletal muscle is constantly being replaced, so the treatment would have to reach its stem cells to avoid the need for repeated injections. Longer studies will be needed to make sure that the CRISPR treatment does not introduce cancer-causing mutations. Even if it safely restores the ability to make dystrophin, the treatment likely will only help boys who receive it early in life because the muscle damage is irreversible. And ultimately the treatment would have to target many other DMD-related mutations to help most boys with the disease. “We have to make sure that we dot all the i’s and cross all the t’s because the implications for both DMD and CRISPR therapy are immense,” Olson says. A colony of dogs at the Royal Veterinary College in London has a mutation that causes a disease similar to Duchenne muscular dystrophy. UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER Fighting fire with fire, researchers working with dogs have fixed a genetic glitch that causes Duchenne muscular dystrophy (DMD) by further damaging the DNA. The unusual approach, using the genome editor CRISPR, allowed a mutated gene to again make a key muscle protein. The feat—achieved for the first time in a large animal—raises hopes that such genetic surgery could one day prevent or treat this crippling and deadly disease in people. An estimated 300,000 boys around the world are currently affected by DMD.The study monitored just four dogs for less than 2 months; more animal experiments must be done to show safety and efficacy before human trials can begin. Even so, “I can’t help but feel tremendously excited,” says Jennifer Doudna of the University of California, Berkeley, who heard the results last week at a CRISPR meeting she helped organize. “This is really an indication of where the field is heading, to deliver gene-edited molecules to the tissues that need them and have a therapeutic benefit. Obviously, we’re not there yet, but that’s the dream.”The study, which also appears online this week in Science, was led by molecular biologist Eric Olson of the University of Texas (UT) Southwestern Medical Center in Dallas, whose team earlier had similar results in mice. “We wanted to put this to the ultimate test and see if we could do it in a large animal,” Olson says. The positive findings—CRISPR quickly restored the protein dystrophin in critical body muscles, including the heart—”brought tears to the eyes and were jaw-dropping,” he says.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)The study offers little evidence that dogs regained muscle function, however, and that, coupled with the short duration of the study and the small number of animals studied, left some scientists less enthusiastic. One researcher in the tight-knit DMD field who asked not to be named wonders whether the study was rushed to help draw investment in Exonics Therapeutics, a Boston-based company Olson launched last year to develop the potential treatment.Olson says his team worked quickly not because of corporate ambitions, but rather to prove the concept before expanding to longer, more thorough dog experiments that ultimately are needed to launch human trials. The few animals initially studied, he adds, reflects sensitivities about experimenting with dogs. “We’re very mindful of ethical concerns and have done our best to keep our use of dogs to an absolute minimum.”The dystrophin gene, the largest in the human body, contains 79 separate coding regions, or exons, that work together to create a protein that has 3500 amino acids. That much DNA offers a lot of opportunities for mutations that can cause DMD. But only one functional copy of the gene is needed, and because it sits on the X chromosome, girls have a backup copy. Boys with their one copy disabled develop walking problems early in life and die on average in their mid-20s from heart and respiratory failure.center_img Gene editing of dogs offers hope for treating human muscular dystrophy Royal Veterinary College Dystrophin (green) is abundant in normal dog muscle cells (left), almost absent in those of a beagle with a muscular dystrophy (middle), and partially restored in an affected beagle treated with CRISPR (right).last_img read more

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Fairmont Kea Lani earns Hotel of the Year distinction

first_imgTags: Fairmont Hotels & Resorts, Hawaii Posted by Tuesday, October 25, 2016 The Fairmont Kea Lani has much to boast about, after earning the distinction of ‘2015 Hotel of the Year’ for the Fairmont Hotels & Resorts Americas region. The all-suite and villa luxury resort was recognized by the brand for achieving best overall operating performance along with outstanding guest satisfaction.Each year Fairmont Hotels & Resorts selects the winner of the Hotel of the Year distinction by combining guest experiences scores with financial performance. Fairmont Kea Lani earned its first place title with exceptional performance scores in each category. The Maui resort was also recognized for launching a guest problem resolution initiative aimed at empowering colleagues to minimize the steps involved in resolving guest issues. This initiative was subsequently adopted by all hotels as a best practice.“We are extremely proud to earn the distinguished recognition of Fairmont Hotels & Resorts 2015 Hotel of the Year,” said Charles Head, general manager, Fairmont Kea Lani on Maui. “It is rewarding to see the resort meet success in each of our brand pillars following the completion of our $70 million renovation and considerable investments in the areas of sustainability and guest experience. Our colleagues are passionate about providing the highest level of service as well as sharing the traditions and culture of Hawaii with our guests.”Guest can discover the essence of Maui at Fairmont Kea Lani, Hawaii’s only all-suite and villa luxury resort. Nestled on the pristine white sands of Wailea’s Polo Beach, this award-winning oceanfront resort features an island inspired spa, culinary and cultural experiences. For more information, visit Fairmont.com/KeaLani. Travelweek Group center_img Share Fairmont Kea Lani earns Hotel of the Year distinction << Previous PostNext Post >>last_img read more

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Japanese restaurant served the last meals of death row inmates

first_img<< Previous PostNext Post >> 毎日死刑囚のラストミール(最後の晩餐)を食べている。今日はジェームスポールジェニーガンの。強盗殺人の罪で薬物注射の刑。盗みに入った家の住人がそのタイミングで帰ってきてしまい、突発的に殺害して有罪。死刑にあたり自分の死体を献体する。1800の部位に切り分けられたにんげんレストラン pic.twitter.com/g1JvjyqvpC— 手塚マキ (@smappatekka) October 17, 2018 Thursday, November 1, 2018 Posted by Tags: Creepy, Japan Japanese restaurant served the last meals of death row inmatescenter_img TOKYO — What do you feel like for dinner? Morbid, with a side of Disturbing perhaps?The Ningen Restaurant in Tokyo raised a few eyebrows this month when it launched a pop-up dining experience during which guests ordered dishes inspired by the last meals of Death Row inmates in the U.S.During the two weeks it was open (it closed on Oct. 28 leading up to Halloween), the pop-up offered meals that included broccoli, asparagus, strawberries, tomatoes and hot tea (the last meal of the Florida ‘Black Widow’ in 1998), and a hamburger, baked potato, hard-boiled egg and three shots of Jack Daniels, which were enjoyed by murderer Gary Mark Gilmore prior to his execution.The morbid concept was the brainchild of art collective Chim↑Pom, and also included a gallery of artwork by Yasuyuki Nishio and Mermann Nitsch.And if the idea of eating criminals’ last meals wasn’t spooky enough, Ningen Restaurant (which also means The ‘Human’ Restaurant) was also housed in the Kabukicho Book Center, a squalid place scheduled for demolition this fall.More news:  Help Princess Cruises break the world record for largest vow renewal at seaWith such disturbing details, we bet diners rushed through their meals. Check, please!甘い香りが漂う店内で、巨大なチョコレートの塊を舐め続ける女のコを見ながら、ハンバーガーにかぶりつき、バーボンを嗜んできました。#にんげんレストラン pic.twitter.com/CHzYxA6Zk4— sequi@ya (@se_qui_ay) October 22, 2018 Travelweek Group 「1人で行きづらい店に同行してほしい」という依頼で「にんげんレストラン」へ。1人で行きづらさ溢れる店構え。写真2枚目はお通しのサプリメント。3枚目は店内にいた「おにぎりを解体する人」4枚目はジョン・ゲイシーという死刑囚(ITのモデル)が最後に食べた料理です。28日で閉店するのでお早めに pic.twitter.com/KXe9Y89XPQ— レンタルなんもしない人 (@morimotoshoji) October 25, 2018 Sharelast_img read more

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