Share on Twitter Share on Facebook LinkedIn Email Neurosurgeons at Barrow Neurological Institute in Phoenix are involved with testing the viability of deep brain stimulation (DBS) to treat Alzheimer’s disease, a disorder that currently has few treatment options. Results from the Phase 2 study, reported in the Journal of Neurosurgery on Dec. 18, 2015, demonstrated the safety of DBS in Alzheimer’s patients.A neurosurgical procedure in which an implanted neurostimulator delivers electrical signals to specific areas of the brain to help regulate abnormal signals, DBS is currently only approved in the U.S. for the treatment of Parkinson’s disease and essential tremor. However, its use is being researched for a number of conditions, including epilepsy, depression and bipolar disorder.Francisco Ponce, MD, Director of the Barrow Center for Neuromodulation, believes there are potential applications for Alzheimer’s disease – the most common form of dementia – as well. Whereas in Parkinson’s disease and essential tremor, the target for the electrodes are nodes within the motor circuits, the Alzheimer’s study targeted the fornix, which is part of the memory pathway. Pinterest Share “There are more than five million Americans living with Alzheimer’s, and yet there are few promising pharmacologic treatment options for this progressive disease,” says Dr. Ponce. “Previous pilot studies researching the use of DBS in Alzheimer’s have indicated the potential to slow cognitive decline in some patients, and have even shown metabolic changes in the brain that may slow the progression of the disease.” Barrow Neurological Institute is part of Dignity Health St. Joseph’s Hospital in Phoenix.The ADvance Trial, using a device from Functional Neuromodulation, Inc., is aimed at evaluating the safety, efficacy and tolerability of DBS in this patient population. Initial research took place between 2012 and 2014 at six hospitals throughout the U.S., including Banner Alzheimer’s Institute in Phoenix and Banner Sun Health Research Institute in Sun City, as well as one institution in Canada. During the trial, 42 patients with mild Alzheimer’s disease underwent the surgical procedure and were closely monitored for adverse effects.Overall, there were no programming-related adverse effects, unanticipated adverse device effects, reported neurological deficits or instances of mortality in the study population. Adverse effects such as headache and infection occurred in 11.9% (5 of 42) of the patients in this study, consistent with rates reported in other DBS trials.“The first phase of this study was designed to evaluate the 90-day postoperative safety of this particular surgical method. While the study was relatively small, we believe the data suggest that DBS surgery targeting the fornix can be performed safely in this patient population. The hope is that our positive surgical experience will help pave the way for future research into DBS and Alzheimer’s,” says Dr. Ponce.Dr. Ponce adds that the next step is evaluating the efficacy and longer-term safety of the treatment, which will not be known until the last patient completes the two-year evaluation later this year.
The Los Alamos High School Hilltoppers Swimming and Diving teams finished second to Albuquerque Academy in both the girls and boys competition Nov. 16 at the 38th Annual Barney Relays at Albuquerque Academy. SPORTS News: The next competition for the Hilltoppers is the 5th Annual Bill Hudson Memorial High School Swimming and Diving Invitational Dec. 6-7. The Hudson meet is usually one on the biggest high school meets in the state with 15 teams and over 300 swimmers and divers. The girls team scores were Albuquerque Academy 176, Los Alamos 134, Cleveland 110, Hope Christian 104, Rio Rancho 56, St Pius 50, Sandia Prep 26, Cottonwood Classical 10. Boys 38th Annual Barney RelaysAlbuquerque Academy ― Nov. 16 ― SQT = State Qualifying Time for LAHS Sophomore Matias Rougier led off the 200 freestyle relay in 23.26, bettering the state meet qualifying time by 0.23 second. The boys 200 medley relay team of frosh Ming Lo, junior Max Corliss, junior Takuma Shiina and junior Konstantin Nelson achieved the state meet qualifying time in finishing second to Academy in the event. They clocked 1:46.01, safely under the qualifying time of 1:53.69. Despite only a few weeks of training, five of Coach Carl Cady’s divers qualified for the state high school meet: sophomore Kyle Hatler, sophomore Annie Beus, junior Daniel Fryer, senior Griffin Stidham, and sophomore Brayden Stidham. Senior co-captain Ian Jaegers led off the mixed (two-gender) 400 medley relay in 54.73, easily below the state high school meet standard for 100 back, although it was unofficial since the relay was a non-standard event. Mixed Diving Relay: Academy 417.35, Los Alamos 409.50 (Kyle Hatler, Katie Wingo), Cleveland 368.70Mixed 400 Medley Relay: Academy 3:47.89 (meet record), Los Alamos 4:08.44 (Ian Jaegers, Max Corliss, Kamaya Ronning, Bailey Yost), Cleveland 4:17.72, Hope 4:22.14, Rio Rancho 4:25.64, Cottonwood 4:26.10, St Pius 4:34.36Girls 200 Free Relay: Academy 1:48.24, Los Alamos 1:53.40 (Sylvia Holesinger, Savannah Kimball, Cory Liechty, Ada Tripp), Hope 1:59.67, Cleveland 1:59.95, Sandia Prep 2:06.78, Rio Rancho 2:08.13, St Pius 2:08.34, Cottonwood 2:36.39Girls 200 Breast Relay: Academy 2:17.69, Los Alamos 2:27.50 (Maddie Ovaska, Bailey Yost, Kamaya Ronning, Katherine Elton), Cleveland 2:30.32, St Pius 2:32.45, Hope 2:41.84, Cottonwood DQGirls 200 Back Relay: Hope 2:06.98, Academy 2:09.73, Los Alamos 2:10.14 (Savannah Kimball, Natalie Aulwes, Maddie Ovaska, Sophie Schmidt), Cleveland 2:14.42, Rio Rancho 2:19.32, St Pius 2:24.75Mixed 400 Free Relay: Academy 3:35.99, Cleveland 3:40.76, Los Alamos 3:45.20 (Cory Liechty, Sylvia Holesinger, Matias Rougier, Ian Jaegers), Hope 4:14.97, St Pius 4:18.23, Rio Rancho 4:39.23, Cottonwood DQGirls 400 IM Relay: Academy 4:22.19, Los Alamos 4:50.81 (Emily McLaughlin, Kezia Tripp, Sophie Schmidt, Katherine Elton), Cleveland 4:55.22, Hope 5:16.47, St Pius 5:19.09, Rio Rancho 5:19.61Girls 200 Butterfly Relay: Academy 1:57.94, Los Alamos 2:02.59 (Kamaya Ronning, Dana Urbatsch, Julia Chen, Katherine Elton), Hope 2:05.34, Cleveland 2:16.26, Rio Rancho 2:31.89, St Pius 2:35.40Girls 200 Medley Relay: Academy 1:57.53, Los Alamos 2:05.41 SQT (Julia Chen, Bailey Yost, Sophie Schmidt, Savannah Kimball), Cleveland 2:12.52, Hope 2:19.45, Sandia Prep 2:34.94, Rio Rancho 2:37.17, St Pius DQMixed 8 x 50 Free Relay: Academy 3:31.98, Hope 3:33.73, Los Alamos 3:41.49 (Max Berndt, Natalie Aulwes, Andrew Watson, Anna Clark, Caleb Kerstiens, Elizabeth Frost, Wayne Williams, Bela Montoya), Sandia Prep 4:07.14, Rio Rancho 4:09.98, Cleveland 4:12.79, St Pius 4:36.11, Cottonwood 5:26.56Girls Team Scores: Albuquerque Academy 176, Los Alamos 134, Cleveland 110, Hope Christian 104, Rio Rancho 56, St Pius 50, Sandia Prep 26, Cottonwood Classical 10 The boys team scores were Albuquerque Academy 180, Los Alamos 134, Cleveland 86, Hope Christian 66, Rio Rancho 60, St Pius 58, Sandia Prep 24, Cottonwood Classical 22. Girls Many Hilltoppers notched personal best individual splits. Middle schoolers Emily McLaughlin and Hayden Sutton made their debut for the Hilltoppers in interscholastic competition. 200 Free Relay: Academy 1:30.29, St Pius 1:38.28, Los Alamos 1:40.01 (Matias Rougier 23.26 SQT, Hayden Sutton, Gabe Katko, Caleb Kerstiens), Cleveland 1:40.93, Rio Rancho 1:44.68, Sandia Prep 1:54.10, Hope 2:21.71, Cottonwood 2:36.17Boys 200 Breast Relay: Academy 1:57.88, Los Alamos 2:06.37 (Takuma Shiina, Max Berndt, Gabe Katko, Andy Corliss), Hope DQ, Rio Rancho DQ, Cleveland DQ, St Pius DQ, Cottonwood DQBoys 200 Back Relay: Academy 1:46.75, Los Alamos 1:49.46 (Ming Lo, Hayden Sutton, Konstantin Nelson, Ian Jaegers), Cleveland 2:07.49, Rio Rancho 2:09.81, St Pius 2:21.22, Hope 2:59.49Boys 400 IM Relay: Academy 3:46.45 (meet record), Los Alamos 3:53.77 (Takuma Shiina, Ming Lo, Andy Corliss, Max Corliss), Rio Rancho 4:17.89, Hope 4:27.54, Cleveland 4:49.62, St Pius DQBoys 200 Butterfly Relay: Academy 1:41.45, Los Alamos 1:42.60 (Matias Rougier, Andrew Watson, Andy Corliss, Konstantin Nelson), Cottonwood 1:58.12, St Pius 2:06.47, Rio Rancho 2:12.11, Hope 2:25.13Boys 200 Medley Relay: Academy 1:42.10, Los Alamos 1:46.01 SQT (Ming Lo, Max Corliss, Takuma Shiina, Konstantin Nelson), Cleveland 1:50.94, St Pius 2:03.63, Sandia Prep 2:09.28, Hope 2:29.29, Rio Rancho DQBoys Team Scores: Albuquerque Academy 180, Los Alamos 134, Cleveland 86, Hope Christian 66, Rio Rancho 60, St Pius 58, Sandia Prep 24, Cottonwood Classical 22 Sophomore Sylvia Holesinger. Courtesy photo The Hilltoppers’ cumulative times for the 15 events were 27.59 seconds faster than at this meet in 2018, or 1.84 seconds per event.
STEMCO, an EnPro Industries company and manufacturer of heavy-duty components and solutions for commercial vehicles, has promoted Jim Reis to the position of vice president of strategy and Doug Hix to the position of vice president and general manager for STEMCO’s Brake Products Group.AdvertisementClick Here to Read MoreAdvertisementIn his new position, Reis will lead STEMCO’s overall strategic efforts, especially in the areas of inorganic growth. He will partner closely with business and functional leads to develop new market opportunities that enable STEMCO to accelerate business growth and planned future development.Reis has more than 30 years of heavy-duty industry experience, much of that with STEMCO, having lead the Brake Products Group as vice president and general manager for the past five years. As vice president and general manager for STEMCO’s Brake Products Group, Hix will carry forward the group’s established strategy to effectively strengthen and further grow the business. Hix will report directly to Reis and work closely with him to transition into this new role.Hix has 10 years of heavy-duty industry experience and has held positions in both operations and finance through his 25-year career. At STEMCO, Hix has served as finance director, and for the past two years, has served as vice president of finance.“On behalf of STEMCO, I am extremely pleased to see Jim and Doug excel in their respective positions and congratulate them on these well-deserved promotions,” said Todd Anderson, president of STEMCO. “I am confident, based on their tremendous amount of knowledge and credibility, that these new leadership appointments will allow us to further pursue our strategy to strengthen, grow and expand our diverse line of products within the commercial vehicle industry.”AdvertisementBoth Reis and Hix will assume their new roles immediately.
Southampton High School senior Caroline Palumbo was one of 34 New York state athletes to earn the title of Positive Multi-Sport Athlete by the Positive Athlete New York program. She will be presented with her award at a New York Mets baseball game July 23.Palumbo earned the award by displaying optimism, care for others, and by always encouraging her teammates to give 100 percent.During her high school career, Palumbo played varsity and junior varsity soccer and served as captain of the varsity winter and spring track teams. She currently holds the school’s 55-meter hurdles record (9.44 seconds), placed fifth in the county in that event this year, and received All-League honors.Along with her athletic participation, she was a member of Athletes Helping Athletes, Natural Helpers, and the student council, as well as president of Best Buddies. The recent graduate, who plans to attend Occidental College in the fall with a double major in Spanish and education, also volunteered her time assisting with the district’s sports program and with Special Olympics.Outside of school, Palumbo is involved with the Southampton Village Volunteer Ambulance program and The Retreat in East Hampton. She did all of this while maintaining a high grade-point average. She is an AP Scholar with Distinction; a member of the National, Latin, and Spanish honor societies; and graduated summa cum laude. firstname.lastname@example.org Share
Pacific Basin Shipping Limited (Pacific Basin) has finalised terms of 12 – year post – delivery export credit agency (ECA) financing in respect of two handymax vessels. These two handymax vessels are already part of the Pacific Basin newbuild fleet and scheduled to deliver by the end of 2013. The facility, which amounts to US$ 50.9 million, has been arranged with Japan Bank for International Cooperation (JBIC), with Citibank Japan Ltd. (Citi) participating as co-financing lender. Citi ’s portion will be secured by insurance from Nippon Export and Investment Insurance (NEXI).Mr. Andrew Broomhead, Chief Financial Officer of Pacific Basin said: “This loan represents an attractive opportunity for us to access additional Japanese ECA financing with a 12 year repayment profile at a time when we are committed to growing our fleet of owned ships. This US$51 million facility is in addition to the US$85 million 12 year Japanese ECA facility announced in April. We are continuing to work actively to secure additional ECA and commercial bank financing with long tenors and associated favourable repayment profiles that we consider beneficial to our shareholders. ”[mappress]Pacific Basin, August 16, 2013
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Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our community Get your free guest access SIGN UP TODAY Subscribe now for unlimited access Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters To continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN
ASIA: A tripartite agreement to complete the 167 km missing section of the planned north–south corridor along the west of the Caspian Sea was reached by the heads of the national railways of Iran, Azerbaijan and Russia during the 60th meeting of the Council for Rail Transport of CIS States during May. Under the agreement Russian Railways is to build the Iranian section of the route between Rasht and the border with Azerbaijan near Astara, while Azerbaijan’s ADDY will be responsible for construction of the section within its territory. Construction of a 165 km line linking Rasht to the Iranian network at Qazvin is now nearing completion with opening planned by the end of this year. Once completed, the cross-border route is expected to carry 1·4 million passengers and 5 to 7 million tonnes of freight a year.Iranian Islamic Republic Railways has applied to become an associate member of the Council for Rail Transport of CIS States.
Malawi orders partial recount in presidential election Malawi hold anti-abortion protests FILE PHOTO: Malasi’s President Peter Mutharika speaks during a past United Nations General Assembly in New York. A court overturned the result of last year’s vote, citing widespread irregularities. /Reuters PhotoMalawi is expected to hold a repeat presidential election on May 19 after a court overturned the result of last year’s vote, citing widespread irregularities.The date was set by Parliament while amending the Electoral Act as ordered by the Constitutional Court’s orders.The amended law allows for a runoff vote in 30 days if no candidate garners the required majority of votes.President Peter Mutharika and the country’s electoral commission have appealed the court ruling.Mutharika however has 21 days to decide whether to approve parliament’s decisions.The nullification of Malawi election results was just the second time that a court invalidated a presidential vote after a Kenyan court did so in 2017.Malawi’s parliament has also recommended that the current electoral commissioners be replaced.Related Zambia to hold presidential poll in August
While a pharmacy major at Toledo by day, Brandon Urasek is now making his mark in the journalism scene specializing in fantasy football and all things Cleveland sports. A five time fantasy football league champ and two time runner-up in ten tries, Brandon strives to help people with their lineups each week in both personal and weekly fantasy leagues in addition to covering the other various Cleveland teams. Follow Brandon on twitter @burasek10 Brandon Urasek Things are a little bit different this week with the holiday. First, I hope everyone has a happy and safe Thanksgiving. I’m going to stick with the typical Sunday/Monday fantasy for the week but I will include the Thanksgiving games as well. Just keep in mind those players that play on Thursday are ineligible for the one I do for my lineup for. Last week was a very low scoring week with the QBs struggling badly. Thankfully I picked one of the few good ones with Newton who helped lead my team to victory. Since I’m doing it so early in the week, my lineup is subject to change based on how things go during the week. But for right now, this is what I got. With that said, let’s get it going again and as always feel free to comment with any questions whether it’s Fanduel or your own fantasy league related, or better yet you can contact me through twitter @burasek10 or email email@example.com Pages: 1 2 3 4 Related TopicsFantasy FootballFantasy Football LikesFantasy Week 12