Long-term stress causes inflammation that erodes memory

first_imgShare Share on Facebook Email Share on Twitter This is the first study of its kind to establish the relationship between short-term memory and prolonged stress. In the case of the mice, that meant repeat visits from a larger, nasty intruder mouse.Mice that were repeatedly exposed to the aggressive intruder had a hard time recalling where the escape hole was in a maze they’d mastered prior to the stressful period.“The stressed mice didn’t recall it. The mice that weren’t stressed, they really remembered it,” Godbout said.They also had measurable changes in their brains, including evidence of inflammation brought on by the immune system’s response to the outside pressure. This was associated with the presence of immune cells, called macrophages, in the brain of the stressed mice.The research team was able to pin the short-term memory loss on the inflammation, and on the immune system.Their work, which appears in The Journal of Neuroscience, builds on previous research substantiating the connections between chronic stress and lasting anxiety.The impact on memory and confirmation that the brain inflammation is caused by the immune system are important new discoveries, Godbout said.“It’s possible we could identify targets that we can treat pharmacologically or behaviorally,” he said.It could be that there are ways to interrupt the inflammation, said John Sheridan, who worked on the study and is associate director of Ohio State’s Institute for Behavioral Medicine Research.The mice used in the study are exposed to repeated social defeat – basically dominance by an alpha mouse – that aims to mimic chronic psychosocial stress experienced by humans.Researchers at Ohio State seek to uncover the secrets behind stress and cognitive and mood problems with a long-range goal of finding ways to help those who are anxious, depressed and suffer from lasting problems, including post-traumatic stress disorder.This new research focused on the hippocampus, a hub of memory and emotional response.The researchers found that the stressed mice had trouble with spatial memory that resolved within 28 days. They found that the mice displayed social avoidance, which measures depressive-like behavior, that continued after four weeks of monitoring.And they were able to measure deficits in the development of new neurons 10 days and 28 days after the prolonged stress ended.When they gave the mice a chemical that inhibited inflammation, neither the brain-cell problem nor the depressive symptoms went away. But the memory loss and inflammatory macrophages did disappear.And that led them to conclude that the post-stress memory trouble is directly linked to inflammation – and the immune system – rather than to other damage to the brain. That type of information can pave the way for immune-based treatments, Godbout said.“Stress releases immune cells from the bone marrow and those cells can traffic to brain areas associated with neuronal activation in response to stress,” Sheridan said. “They’re being called to the brain, to the center of memory.”center_img Pinterest Sustained stress erodes memory, and the immune system plays a key role in the cognitive impairment, according to a new study from researchers at The Ohio State University.The work in mice could one day lead to treatment for repeated, long-term mental assault such as that sustained by bullying victims, soldiers and those who report to beastly bosses, the researchers say.“This is chronic stress. It’s not just the stress of giving a talk or meeting someone new,” said lead researcher Jonathan Godbout, associate professor of neuroscience at Ohio State. LinkedInlast_img read more

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Study: Contact tracing slowed COVID-19 spread in China

first_imgIsolation and contact tracing—which are now key topics as US officials discuss plans to open up the country—helped control the spread of COVID-19 in Shenzhen, China, according to a study published yesterday in The Lancet Infectious Diseases.In the first known coronavirus research of its kind, researchers studied 391 COVID-19 patients and their 1,286 close contacts—identified through symptomatic surveillance and contact tracing from Jan 14 to Feb 12—to characterize disease course, transmission, and the effect of control measures.After 622 of 653 close contacts with known quarantine dates were followed for at least 12 days, 98 tested positive, and one had presumed infection. Assuming that contacts with missing test results were not infected, the researchers estimated an attack rate of 11.2% (95% confidence interval [CI], 9.1 to 13.8) among household contacts and 6.6% (95% CI, 5.4 to 8.1) overall.Risk of infection was highest for household contacts (odds ratio [OR], 6.27; 95% CI, 1.49 to 26.33) and those traveling with an infected person (OR, 7.06; 95% CI, 1.43 to 34.91). Infection was as common in children as in adults (7.4% in children younger than 10 years; average, 6.6% in overall population). Mode of detection was known in 379 of the 391 patients. Of them, 292 (77%) were identified through symptom-based surveillance, and 87 were identified through contact tracing.Rapid isolation of infected peoplePatients identified through symptom-based surveillance were identified and isolated, on average, 4.6 days after symptom onset (95% CI, 4.1 to 5.0). Contact tracing reduced this time to 2.7 days (95% CI, 2.1 to 3.3).The reproductive number (R0, or R-naught) was low, at 0.4 (95% CI, 0.3 to 0.5). The R0 indicates degree of infectiousness by showing how many people a single person can infect with a virus. If the R0 is less than 1, an outbreak dies; if the average is greater than one, it spreads. The authors said that their analysis shows the effectiveness of contact tracing and isolation in reducing transmissibility of COVID-19, while noting that the overall impact of isolation and contact tracing is unclear and highly dependent on the number of asymptomatic patients.”Contact-based surveillance in Shenzhen reduced the duration an infected individual transmits in the community by 2 days,” they wrote. “We provide a key piece of evidence supporting intensive contact tracing and highlighting that children might be an important target for interventions aimed at reducing transmission, even if they do not get sick.”Mean serial interval, the time between successive cases, was 6.3 days (95% CI, 5.2 to 7.6). In the 183 patients with a well-defined exposure period and illness onset, the authors estimated a median incubation period of 4.8 days (95% CI, 4.2 to 5.4).Infected patients were older than the rest of the population, with a mean age of 45 years, and were nearly equal in terms of sex. On initial assessment, 356 of 391 (91%) of patients had mild or moderate illness, while 35 (9%) were severe. While 330 (84%) of 391 patients had a fever, 25 (6%) were asymptomatic. In the contact-based surveillance group, 17 of 87 (20%) of patients had no symptoms at initial assessment.As of Feb 22, three patients had died, and 225 had recovered, with a median time to recovery of 21 days (95% CI, 20 to 22).In a commentary in the same journal, Kaiyuan Sun, PhD, and Cecile Viboud, PhD, of the US National Institutes of Health said that the serial interval in the study should be considered a lower bound that would likely increase in areas with less-controlled outbreaks.Noting that contact tracing is labor-intensive and not always accurate when done manually, they called for new technology-based measures. “Building on the SARS-CoV-2 response in Shenzhen and other settings, we content that enhanced case finding and contact tracing should be part of the long-term response to this pandemic—this can get us most of the way towards control,” they wrote.last_img read more

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VP, Store Operations – Uni-Select, USA Inc.

first_imgLSI President Brett Tennar says, “Steve’s success in developing operational strategies that improves the bottom line, builds teamwork, reduces waste and ensures quality product development and distribution checks many of the boxes of what we were looking for in a COO. This, coupled with his career in the Air Force working with highly technical systems and his in-depth understanding of Lean Six Sigma and Business Process Management sealed our offer. As our tagline states, our products are Powered by Science. This data driven approach is one reason why our company has grown exponentially as we employ the most advanced technology to product development. I am confident that Steve is the right person to drive operational strategy for our diverse and growing brands.” Advertisement DeMoulpied comes to LSI from the Private Client Services practice of Ernst & Young where he managed strategy & operations improvement engagements for privately held client businesses. Some of his prior roles include VP of strategic development, director of strategic initiatives, and Lean Six Sigma Master Black Belt at OptumHealth, UnitedHealth Group’s health services business, as well as Lean Six Sigma Black Belt at General Electric, where he applied operations improvement principles to customer service, supply chain and product development. A successful entrepreneur, deMoulpied is also the founder of PrestoFresh, a Cleveland-based e-commerce food/grocery business.  Uni-Select USA is the largest independent automotive parts distributor in the United States with multiple locations throughout the country. We offer excellent benefits, training and competitive wages. Uni-Select USA has an excellent employment opportunity for a VP, Store Operations.    The incumbent is responsible for implementing the successful operation of all corporate stores in the USA Business Unit and is responsible for the Corporate Stores execution to increase growth and profitability.  As a seasoned operator in this strategic role, the incumbent will develop growth objectives as well as profit objectives for the stores.AdvertisementClick Here to Read MoreAdvertisement Requirements:  • 5-7 years experience with installer and wholesale sales and operations. • 5-7 years customer service field experience in the automotive aftermarket industry. • 10-15 years proven track record of growing sales and managing expenses. • 15-20 years of working knowledge of aftermarket products, product lines and business models. • Must possess excellent management and leadership skills. • Must be able to build and maintain a network of relationships and utilize a coaching style that fosters teamwork. If interested, click the Apply Now button below to apply.,Lubrication Specialties Inc. (LSI), manufacturer of Hot Shot’s Secret brand of performance additives and oils, recently announced the expansion of senior leadership. Steve deMoulpied joins LSI as the company’s chief operating officer (COO). AdvertisementClick Here to Read MoreAdvertisement With more than 20 years of experience across multiple industries and functional areas, deMoulpied has particular expertise in organizations with complex technical products. Combined, his prior positions have required a spectrum of skills in corporate strategy, operations improvement, product quality, and revenue cycle management. He has an impressive history of utilizing data driven problem solving (Lean Six Sigma) and project management (PMP and CSM) to achieve strategic goals surrounding customer satisfaction, operational efficiency and improved profit.  DeMoulpied has a Bachelor of Science degree in Engineering Management from the United States Air Force Academy and a Master of Business Administration degree from the University of Dayton in Marketing and International Business. He served six years with the USAF overseeing the development of technology used on fighter aircraft and the E-3 Surveillance aircraft, finishing his career honorably as Captain.last_img read more

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Shelter Cove Marina Dredging Proposed

first_imgThe U.S. Army Corps of Engineers, Charleston District, is receiving written comments on the proposed maintenance dredging of the Shelter Cove Marina, Hilton Head Island, SC.According to the Corps, an application has been submitted by the Shelter Cove Marina/Greenwood Communities and Resorts for a permit to perform maintenance dredging of the entrance channel and marina basin.In detail, the applicant requested authorization under a ten-year maintenance permit to perform an initial, limited dredging of the marina basin that would utilize the remaining capacity of their existing upland confined disposal facility (CDF).The proposed dredging of the entrance channel and a marina basin at Shelter Cove Marina calls for the removal of approximately 29,000 cubic yards of sediment. Following the completion of the project, the entrance channel would be -5 ft MLLW deep.Future maintenance efforts (to be performed under this same authorization) will involve hydraulically dredging approximately 70,000 cubic yards of the marina basin and entrance channel to its originally permitted depth of -9 MLLW.The deadline for sending written comments on the proposed work is Thursday, February 23, 2017.last_img read more

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Construction law predictions: Fortune telling

first_imgI knew that crystal ball gazing was a mug’s game – why did I allow myself to do it in my first column for 2014? Commenting on a case which told us that collateral warranties could carry the right to adjudicate, I aggressively asserted that “some misguided lawyers” have argued that third party rights should be used to avoid bringing in the right to adjudicate. I confidently stated that third party rights which are part of a “construction contract” must include the right to adjudicate if collateral warranties did. And now I have to eat cold Christmas pudding. In November, Mr Justice Ramsey decided absolutely the opposite of what I had predicted and did not allow Barclays Bank plc to refer disputes to adjudication under the third party rights granted to them by Hurley Palmer Flatt Limited. Under the Construction Act and the scheme, he said, Barclays, as third party, were not “a party to a construction contract”, therefore, the scheme could not apply. The only way of ensuring that adjudication applied to the third party rights as well as the consultancy agreement was to say so. How wrong can you be? My grovelling apologies to all lawyers everywhere and a New Year’s resolution to be more hesitant about expressing any opinion about anything, however obvious it seems.But what a ridiculous mess at a practical level. Collateral warranties will usually carry the right to adjudicate but third party rights will not.  Funders, purchasers and tenants will usually want the right to adjudicate but consultants and contractors will prefer that they do not have it. I make no predictions about how this can be sorted out in practice …Now I have to eat cold Christmas pudding. In November, Mr Justice Ramsey decided absolutely the opposite of what I had predictedMr Justice Ramsey retired from the TCC with a bang. I mentioned in that column of 2014 his hint in Liberty Mercian vs Cuddy Civil Engineering Limited that he might consider specific performance of an obligation to deliver collateral warranties. In the 2013 instalment of this long-running saga, Mr Justice Ramsey had sent Cuddy off to take appropriate steps to obtain the performance bond it had contracted to provide. Because the building contract had already been terminated, the relevant Cuddy entity was non-trading and had no assets and litigation was already in progress, Cuddy could not, despite trying in the early part of 2014, find a surety except for an unrated company based in Gibraltar who required the cash equivalent of the bond amount to be deposited with it before it would issue the bond. So Mr Justice Ramsey ordered Cuddy to pay the amount of the performance bond into court, leaving the court to act as surety.And in relation to a subcontractor’s collateral warranty which Cuddy had also agreed to provide, Mr Justice Ramsey ordered Cuddy to obtain it even though the subcontractor had gone into liquidation and been removed from the Companies House register. Just how Cuddy will do that remains to be seen – chapter three of the saga in next year’s column.Did I get any predictions right last year? A couple:Construction lawyers are not rewriting construction contracts wholesale to deal with BIM. Nor is it “bombing” as Tony Bingham predicted – at least someone else gets things as wrong as me.The industry has been working and not pontificating – albeit perhaps too hard – as lead times extend, single stage tendering virtually disappears, material prices inflate and working hours lengthen. And it does all seem to be based on asset bubbles in the South-east. So I got that right too.And dare I attempt any predictions for 2015?  Just two very cautious ones:Things will calm down. There will be fewer ill-prepared new starts and we can all work at a more measured pace.Government will wake up to the costs of bad practice and corruption in the construction industry. The Competition and Markets Authority’s advice on bid rigging agreements in November was an encouraging start. Email cartelshotline@cma.gsi.gov.uk with the evidence to make my prediction come true…Happy New Year.Ann Minogue is a partner in Macfarlaneslast_img read more

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How digital age strengthens in-house professionals

first_imgI am delighted to be writing for the Law Society Gazette as an in-house lawyer in industry. The Law Society represents and services the interests of 126,000 solicitors. Some 33% of these lawyers are working in house. Everyone has seen the very positive continuing developments recently at the Gazette as the Society continues to embrace electronic and digital media. Daily news updates are now being sent by email to solicitors who can now access developments as and when they occur, whether they are working in our country or whether they are practising as solicitors elsewhere around the globe. All manner of solicitors across our profession are benefiting, be they lawyers working in-house or for government, sole practitioners, solicitors in high street firms or commercial lawyers working for regional, City, US and international practices. The daily updates carry an excellent range of news and features that are of interest to all of the different segments of our profession. As a result, more and more lawyers are now seeing more of what is happening across the broader legal community. We are also learning more about how the Society itself is working for each of the different segments of our profession. This is not only in the UK itself, but the Society also works in jurisdictions across the world to maximise the opportunities for our profession. This may be, for example, to allow solicitors to provide services in other countries, so we can service companies and institutions who may be overseas. Everything we do as lawyers, whether in an office or courtroom, will at some stage rely on successful communication. The success of our clients’ and stakeholders’ transactions, cases and matters will depend on the influence that such communication carries. The continuing developments at the Society and the Gazette to embrace electronic communication and digital media will be of benefit to the entire legal community. Ed Gretton is an in-house lawyer running a legal function in industry, as head of legal at Hansonlast_img read more

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Five new stations funded

first_imgUK: The allocation of £16m from the New Stations Fund to enable to the construction of five stations was announced by the Department for Transport on July 28. All of the stations will be fully accessible and are scheduled for completion by March 2020.This is the second round of funding from the New Stations Fund, which has previously supported the stations at Newcourt (Exeter), Lea Bridge (London), Pye Corner (Newport) and Ilkeston, which are now open, and Kenilworth which is expected to be completed later this year. ‘New stations are proven to have a hugely positive effect on local areas, acting as a catalyst for regeneration driving social and economic improvements’, said Network Rail Property Managing Director David Biggs. StationDfT funding, £mProject cost, £mNotes Horden Peterlee, County Durham4·410·55Improving access to employment opportunities in an area with low levels of car ownership Warrington West, Cheshire4·2317·2Reducing congestion on the M62 motorway and supporting the Chapelford Urban Village housing development Reading Green Park2·316·5’The potential to unlock 7 500 new jobs and 1 500 homes’ in an area currently only accessible by road Bow Street, Ceredigion3·9456·76Park and ride for Aberystwyth and Borth Portway Parkway, near Bristol1·6722·23 Serving an existing park and ride sitelast_img read more

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Plans move forward for Tropical Smoothie Cafe in Farmington

first_img admin Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Pinterest (Opens in new window) Farmington Planning Commissioners voted Monday to move forward plans that will bring a Tropical Smoothie Cafe to a Grand River shopping center, but with multiple conditions.Most importantly, commissioners wanted assurances that the owner of the World Wide Center would follow through with repairs to the existing building, in addition to putting up a 1700-square-foot building on the east side of the parking lot.Consultant Matt Parks of OHM Advisors said while engineering and planning reviews found a number of issues that need to be addressed, none was serious enough to stop the project. Among the items he discussed were bringing sidewalks and ramps up to Americans with Disabilities Act standards and adding more detail about stormwater drainage, building materials, and building canopy clearances.“Landscaping is the area that probably needs the most work,” Parks said. “What was submitted falls very much short of what was required.”Plans show removal of 15 out of 16 trees in place along Grand River, which Parks said would be find but with additional landscaping features added. He suggested ornamental trees, a hedgerow, or landscape terrace. He also suggested plantings around the building.The city’s Zoning Board of Appeals granted a variance that will allow for the removal of 37 parking spots and a reduction in the number of drive-through “stacking” spaces from the required 10 to seven. Parks said the reduction in parking spaces will likely improve circulation on the site and make some spaces more accessible.Public hearingOne resident spoke during a public hearing on the proposal. Robert Kull lives on Whittaker Drive, not far from the center. He said that lighting from the center spills over into his neighborhood, an issue that the plan addresses.“That’s been a problem for five years,” he said, adding that he doesn’t have confidence the property owner will address issues unless they’re brought up during the hearing.Kull was also concerned about sound from the drive-through speakers, which are pointed toward the existing building and asked for a requirement that sound won’t carry into neighborhoods. Noting that visitors to the Panera restaurant east of the center park on Whittaker, he asked whether the city could restrict parking on the street.Kull’s request that the approval include a restriction on business hours was part of the final motion for approval, along with a raft of other conditions that included items listed on the planning and engineering reviews.“This is currently proposed as a Tropical Smoothie Cafe, but it may be something different in the future,” he said.Planning Commissioner Steve Majoros asked whether the commission had control over business hours. Economic and Community Development Director Kevin Christiansen said commissioners could add “any reasonable conditions it deems necessary. That can certainly include things like how a business operates, hours of operation included. You have that latitude as a planning commission.”Majoros also asked whether the commission could make improvements to the existing building a condition of approval for the outbuilding. However, World Wide Center representative John Moran said the work must be done concurrently, in order to complete the building on time for the new tenant.He suggested making the improvements part of the scope of work for the building permits, so that Certificates of Occupancy would be “contingent on the full scope of the work.”“We understand the safeguard,” he said. “We just ask for consideration, so we can do it, in both cases, sooner than later.”READ MORE: TROPICAL SMOOTHIE CAFE MAY MOVE TO FARMINGTON STRIP CENTER Reported bylast_img read more

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Bringing Wireless Gigabit Networks to American Communities

first_imgSiklu,a developer of millimeter-wave technology, and Las Vegas, Nevada based Broavada Communications, LLC, a subsidiary of the national technology consulting firm, The Broadband Group, have announced a partnership to accelerate the deployment of millimeter wave Gigabit wireless networks. Siklu offers small, millimeter wave based, multi-Gigabit radio solutions, applicable to a wide range of Ethernet deployment scenarios. The products are ideal for communities that require Gigabit connectivity, but do not enjoy the economies of scale to “rebuild” pure fiber networks.This unique partnership will bring new opportunities to the industry and provide the excellence needed to meet the needs of next generation connectivity. The personality and destiny of any great city or community is in how it defines its ability to communicate across many disciplines. This partnership is poised to significantly advance that agenda. The Siklu multi-Gigabit throughput radios are the market’s most cost-effective solutions for short-range fiber like wireless point-to-point links. The technology is based on radio frequency transmission in the unlicensed V-Band and the lightly licensed E-Band. These run in the 60-80 GHz range. They are based on more than 30 patents, and include the first SiGe E-band chip and other unique achievements. Siklu has sold and deployed tens of thousands of radios worldwide to service providers, mobile operators, wireless security network operators, and enterprises.Kirshenbaum (Siklu’s Co-Founder, Chairman and President) noted “We recognize the significance that Gigabit enabled telecommunications facilities will inevitably have on how we communicate and the way we live our lives. The benefits that abundant bandwidth provides should not be limited to only those communities that have the economics supporting a pure fiber network build out,” said Tom Reiman, the President of Broavada Communications and Founder of The Broadband Group.   “While The Broadband Group maintains its independent role as a neutral advisor to our clients, we recognize the need to bring innovative new products and services to the industry through Broavada Communications.  Siklu is an ideal partner to advance that agenda. Broavada and Siklu have joined forces at a critical time in the growing relevance of broadband infrastructure and services.”  Reiman added, “Our goal is to completely understand the operational, financial, and regulatory issues that must be addressed to make certain homes, offices, and Community Anchor Institutions have immediate access to the most advanced communication infrastructure possible.  Once this is achieved, we see Siklu finding a place in the market with innovative service providers throughout North America.””Working together, Siklu and Broavada (The Broadband Group) will find and select communities that might benefit from this infrastructure and its services. Reiman adds, “We will determine how these facilities might best be managed, connected, and designed to serve residential and commercial customers in the target communities. If we do this right, we recognize the significant influence this may also have on regional economic development efforts.” said Tom Reiman, the President of Broavada Communications and Founder of The Broadband Group.last_img read more

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Sullivan | Kentucky lacking without Ulis

first_img Session ID: 2020-09-18:d1fc45c05b83146afc4aad2c Player ID: videojs-brightcove-player-808415-4638832444001 OK Close Modal DialogCaption Settings DialogBeginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsDefaultsDoneClose Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Video | John Calipari details Illinois State win, previews UCLAVideo | UK’s Marcus Lee on big bouncebackPlay VideoPlayMuteCurrent Time 0:00/Duration Time 0:00Loaded: 0%0:00Progress: 0%0:00 Progress: 0%Stream TypeLIVERemaining Time -0:00 Playback Rate1ChaptersChaptersdescriptions off, selectedDescriptionssubtitles off, selectedSubtitlescaptions settings, opens captions settings dialogcaptions off, selectedCaptionsAudio TrackFullscreenThis is a modal window. The Video Cloud video was not found. Error Code: VIDEO_CLOUD_ERR_VIDEO_NOT_FOUND “He runs our pack,” forward Marcus Lee said of Ulis Monday night. “He’s our well-oiled machine. He makes sure everything flows perfectly.”Here, Lee paused in mid-thought to impart some positive spin.“Without him, it let our other guards step up and figure things out,” he said. “Even though they’re freshmen, they got the time to be point guards without Tyler and figure things out on their own. For us, it helped us a whole lot more.”Briscoe overcame his wobbly start to score 18 points and demonstrated his versatility with seven rebounds, but he also fouled out in 27 minutes of playing time. Murray, too, opened the game ominously – “The first half, I thought he was non-existent,” Calipari said, but ultimately totaled 16 points.Despite their ranking and 7-0 record, Kentucky heads to UCLA for a Thursday game less experienced than last season and more vulnerable. Unless Ulis heals in the interim, the Wildcats’ first true road game of the season could prove a daunting assignment, despite their dominance of the Bruins a year ago.“If he’s not healthy, it’s bad timing,” Calipari said. “But we’ll see. He was half coaching on the bench, telling me who to take out.”When Calipari asked which player he wanted replaced, Ulis replied, “You know who.”He probably did. But Calipari’s alternatives were limited Monday night. Tyler Ulis was unavailable.Tim Sullivan can be reached at (502) 582-4650, tsullivan@courier-journal.com or @TimSullivan714 on Twitter. Session ID: 2020-09-18:b9a055b117ede92c908f209e Player ID: videojs-brightcove-player-215713-4638454186001 OK Close Modal DialogCaption Settings DialogBeginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsDefaultsDoneClose Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.11/30/15, 10:05 PMVideo | UK G Isaiah Briscoe overcomes slow start vs. Illinois StatePlay VideoPlayMuteCurrent Time 0:00/Duration Time 0:00Loaded: 0%0:00Progress: 0%0:00 Progress: 0%Stream TypeLIVERemaining Time -0:00 Playback Rate1ChaptersChaptersdescriptions off, selectedDescriptionssubtitles off, selectedSubtitlescaptions settings, opens captions settings dialogcaptions off, selectedCaptionsAudio TrackFullscreenThis is a modal window. The Video Cloud video was not found. Error Code: VIDEO_CLOUD_ERR_VIDEO_NOT_FOUND Session ID: 2020-09-18:9b247637788446d9b34b1e35 Player ID: videojs-brightcove-player-454826-4638832447001 OK Close Modal DialogCaption Settings DialogBeginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsDefaultsDoneClose Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Video | UK G Isaiah Briscoe overcomes slow start vs. Illinois StateVideo | UK G Jamal Murray steps up in second half vs. Illinois StatePlay VideoPlayMuteCurrent Time 0:00/Duration Time 0:00Loaded: 0%0:00Progress: 0%0:00 Progress: 0%Stream TypeLIVERemaining Time -0:00 Playback Rate1ChaptersChaptersdescriptions off, selectedDescriptionssubtitles off, selectedSubtitlescaptions settings, opens captions settings dialogcaptions off, selectedCaptionsAudio TrackFullscreenThis is a modal window. The Video Cloud video was not found. Error Code: VIDEO_CLOUD_ERR_VIDEO_NOT_FOUNDcenter_img Session ID: 2020-09-18:a643574ef0b321f1ab28b2b4 Player ID: videojs-brightcove-player-368001-4638881626001 OK Close Modal DialogCaption Settings DialogBeginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsDefaultsDoneClose Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Video | UK G Jamal Murray steps up in second half vs. Illinois StateNov 30, 2015; Lexington, KY, USA; Kentucky Wildcats guard Jamal Murray (23) dribbles the ball against Illinois State Redbirds forward MiKyle McIntosh (11) in the second half at Rupp Arena. Mandatory Credit: Mark Zerof-USA TODAY SportsNov 30, 2015; Lexington, KY, USA; Kentucky Wildcats guard Jamal Murray (23) dribbles the ball against Illinois State Redbirds forward MiKyle McIntosh (11) in the second half at Rupp Arena. Mandatory Credit: Mark Zerof-USA TODAY SportsLEXINGTON, Ky. – No. 1 needs its No. 3.Kentucky without Tyler Ulis is a sports car without a steering wheel. It is an orchestra without a conductor. It is a collection of valuable parts with a whole lot of assembly required.Playing without its primary and most experienced point guard Monday night, the nation’s top-ranked team moved in fits, starts and sometimes in reverse. The Wildcats’ 75-63 victory over Illinois State was a testament to superior talent, but it was also a reminder of how the absence of a single player can spell the difference between cohesion and chaos.“Without Tyler, it’s obvious we’re not the same team,” Kentucky coach John Calipari said. “I mean, unless you were watching another game.”Resisting Ulis’ willingness to test the hyperextended right elbow he suffered Friday, Calipari started three freshmen guards against the Redbirds and watched them combine for 12 turnovers – three of them by Isaiah Briscoe in the game’s first 89 seconds – in a game that was tied at the half, 31-31.Instant Analysis | UK wins ugly without UlisBriscoe, Jamal Murray and Charles Matthews are all gifted guys – Briscoe and Murray both project as first-round draft choices by NBAdraft.net – but though they tower over the (purportedly) 5-foot-9 Ulis, they have yet to attain his stature in terms of basketball efficiency.“It was a big difference,” Briscoe said. “We missed him out there, of course. He’s a leader and our floor general, so we missed him today.”In the scheme of a long season, that difference is not a serious knock on these freshmen at this stage of their development. The list of college point guards comparable to Tyler Ulis likely numbers in single digits. The list of those who have made Duke coach Mike Krzyzewski gush is shorter still.To review:“He is in complete control of his team,” Coach K said after Kentucky’s 74-63 victory over his Blue Devils on Nov. 17. “Competing against him, I admired his presence throughout the game and his face throughout the game. It was the face of a winner and a really good winner.”Despite his modest size, Ulis typically stands out as the quickest guy on the floor. But that favorable first impression inevitably gives way to a broader appreciation of his instincts, his judgment and the rare ability to make the game appear to slow down even as he’s speeding up.As a freshman last season, consigned to Calipari’s second platoon, Ulis was credited with 135 assists against just 38 turnovers, a ratio that improved to 15-4 during the NCAA tournament. Briscoe and Murray may have higher ceilings, but Ulis is the one Kentucky fans want running the show in a tight spot. (At the risk of belaboring a painful point, it’s almost inconceivable that the Wildcats could have created three straight shot-clock violations had Ulis been in charge in the decisive minutes last spring against Wisconsin.) Story continues after the gallery. Video | John Calipari details Illinois State win, previews UCLAPlay VideoPlayMuteCurrent Time 0:00/Duration Time 0:00Loaded: 0%0:00Progress: 0%0:00 Progress: 0%Stream TypeLIVERemaining Time -0:00 Playback Rate1ChaptersChaptersdescriptions off, selectedDescriptionssubtitles off, selectedSubtitlescaptions settings, opens captions settings dialogcaptions off, selectedCaptionsAudio TrackFullscreenThis is a modal window. The Video Cloud video was not found. Error Code: VIDEO_CLOUD_ERR_VIDEO_NOT_FOUNDlast_img read more

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